COMPARISON BETWEEN DIFFERENT COMERICAL BRANDS OF MELOXICAM AND THEIR DEGRADATIONS AVAILABLE IN ZAWIA PHARMACIES, LIBYA

  • Mustafa A. Benamer Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Zawia University, Libya
  • Salma G. Zbeda Department of Chemistry, Faculty of Science, Azzaytuna University, Libya
Keywords: Meloxicam, commercial, degradation, ultraviolet, spectrophotometer

Abstract

Meloxicam is an enolic acid derivative, which is the most important of the non-steroidal anti-inflammatory drug (NSAID). The objective of this work was to measure the absorbance of commercial meloxicam brands and their percentage of degradations under different conditions, as defined under the International Conference on Harmonization (ICH) guideline by using a spectrophotometer. The degradation behaviour of meloxicam was studied by subjecting the different brands of meloxicam to hydrolytic (acidic and basic), photolytic (Ultraviolet) and thermal stress. The collected data helped to identify the degradation products of the drug. The results showed a different pattern of degradation in all cases.

Author Biographies

Mustafa A. Benamer, Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Zawia University, Libya

Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Zawia University, Libya

Salma G. Zbeda, Department of Chemistry, Faculty of Science, Azzaytuna University, Libya

Department of Chemistry, Faculty of Science, Azzaytuna University, Libya

Published
2021-10-18
How to Cite
Benamer, M., & Zbeda, S. (2021). COMPARISON BETWEEN DIFFERENT COMERICAL BRANDS OF MELOXICAM AND THEIR DEGRADATIONS AVAILABLE IN ZAWIA PHARMACIES, LIBYA. Scientific Journal of Applied Sciences of Sabratha University, 1-8. Retrieved from https://jas.sabu.edu.ly/index.php/asjsu/article/view/164